




migradex Ingredients Praised
See how migradex changes lives in just 6 weeks
92%
Experienced better overall quality of life¹*
85%
Noticed that migradex has significantly reduces number of migraine attacks by 70 %.¹*
76%
Noticed that migradex reduces migraine symptoms by 72%.¹*
¹ based on migradex's ingredients human studies
Science behind migradex
Magnesium + Vitamin D
Vitamin D increases magnesium's absorption and utilization leading to better effect at lower dose
Riboflavin + Magnesium + Vit B6
These unique combination increases each other's absorption and works synergistically to reduce number of attacks
Feverfew + Vit B1 + CoQ10
This trio will not only reduces number of attacks but also reduces severity of attack so you dont have to keep taking harsh abortive pills

Vascular Muscle Relaxation
Neuroinflammation Reduction
CGRP Inhibition
Homocysteine Regulation
Mitochondrial Support
The combination helps regulate vascular tone by reducing levels of nitric oxide, prostaglandins, and histamine in blood vessels, thereby decreasing both the frequency and intensity of migraine attacks.
Riboflavin and magnesium work synergistically to decrease neuronal inflammation, moderating nerve transmission and reducing attack frequency. This dual-action approach helps maintain neural homeostasis.
CoQ10 lowers the level of Calcitonin Gene-Related Peptide (CGRP), a key pain signaling protein. This mechanism significantly reduces monthly migraine occurrences.
Elevated homocysteine levels, often associated with MTHFR gene mutations, are a significant migraine trigger. Vitamin B6 and folate facilitate homocysteine metabolism, helping to prevent attacks through improved methylation.
Migraines are frequently linked to mitochondrial dysfunction caused by nutritional deficiencies. This comprehensive formula addresses these deficits by providing essential vitamins and magnesium, supporting optimal mitochondrial function.
Ingredients
Each Ingredient is accurately dosed by pharmacist referencing more than 104 human studies to provide maximum efficacy.
Magnesium (bisglycinate)
Riboflavin
Coenzyme Q10
Thiamine
Feverfew
Vitamin B6
Vitamin D3
Folic acid
FAQ
Is migradex Safe?
Is migradex Safe?
Yes, migradex is made with all natural ingredients that are generally considered safe when taken as directed. However, it is important to consult with your healthcare provider before starting any new supplement, especially if you have underlying health conditions or are taking other medications such as warfarin (coumadin)*
Who should not take migradex?

Who should not take migradex?
migradex should not be used by children less than 18 years of age and pregnant and breastfeeding mothers.*
No Butterbur?

No Butterbur?
Many clinical trials suggest that butterbur is very effective in reducing migraine attacks. However, the American Headache Society no longer recommends the use of butterbur as it contains pyrrolizidine alkaloids (PAs), which can cause liver damage. We tested seven different PA-free extracts and found that all of them contained trace amounts of PAs. Since safety is our first priority, we decided not to include butterbur in our formulation.*
Urine color change?

Urine color change?
The change in urine color is due to riboflavin (vitamin B2). Excess riboflavin is excreted via urine, which can change its color to bright yellow or orange. This color change is completely harmless and indicates that your body is utilizing the vitamins effectively.*
How migradex compares to prescription medications

How migradex compares to prescription medications
There are very few prescription options available for preventing migraines, and most of them have undesirable side effects. Being a natural formulation, Migradex doesn't have side effects and works just as well, if not better. Additionally, Migradex targets root causes like nutritional deficiencies and homocysteine metabolism that prescription medications doesn't.*
Testimonials
Collapsible content
Clinical References
Clinical References
Riboflavin (Vitamin B2)
- Experimental and Clinical Evidence of the Effectiveness of Riboflavin on Migraines. Nutrients2021, 13, 2612. LINK
- Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. Int. J. Mol. Sci. 2020, 21, 950 LINK
- Effect of riboflavin status on the homocysteine lowering effect of folate in relation to the MTHFR (C677T) genotype. Clin. Chem. 2003, 49, 295–302. LINK
- Oral riboflavin in migraine prophylaxis: An open label randomized controlled trial. Neurol. Asia 2011, 16, 223–229. LINK
- Riboflavin as a photosensitizer. Effects on human health and food quality. Food Funct. 2012, 3, 487–502. LINK
- Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. LINK
- Boehnke, C., et al. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol, 2004. PMID: 15272863
- Schoenen, J., et al. Effectiveness of high-dose riboflavin in migraine prophylaxis. Neurology, 1998. PMID: 9484373
Coenzyme Q10
- Sandor, P. S., et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology, 2005. PMID: 15728297
- Hershey, A. D., et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache, 2007. PMID: 17305328
Feverfew
- Johnson, E. S., et al. Efficacy of feverfew as prophylactic treatment of migraine. BMJ, 1985. PMID: 3927985
- Murphy, J. J., et al. Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet, 1988. PMID: 2899772
Vitamin D
- Zandifar, A., et al. Vitamin D status in migraine patients: a case-control study. Biomed Res Int, 2014. PMID: 24729938
- Gazerani, P., et al. A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine. Curr Med Res Opin, 2019. PMID: 30588823
Vitamin B1 (Thiamine)
- Altura, B. M., & Altura, B. T. Magnesium, thiamine and vascular tone and reactivity: relationship to migraine. Magnesium, 1982. PMID: 6761562
Vitamin B6
- Menon, S., et al. The role of MTHFR gene variants in migraine. Mol Genet Metab, 2011. PMID: 21546185
- Peikert, A., et al. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia, 1996. PMID: 8823975
Folic Acid
- Frosst, P., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet, 1995. PMID: 7647779
- Lea, R., et al. The use of vitamin supplements in the treatment of migraine. Med Hypotheses, 2004. PMID: 15288371
Magnesium
- Mauskop, A., & Altura, B. T. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci, 1998. PMID: 9533522
- Ramadan, N. M., et al. Low brain magnesium in migraine. Headache, 1989. PMID: 2618945