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subscribe and save 16.66% just like 79% of our customers

subscribe and save 16.66% just like 79% of our customers

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subscribe and save 16.66% just like 79% of our customers

subscribe and save 16.66% just like 79% of our customers

subscribe and save 16.66% just like 79% of our customers

subscribe and save 16.66% just like 79% of our customers

subscribe and save 16.66% just like 79% of our customers

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Pharmacist formulated

migradex

migradex

✔️ Starts working within weeks*

✔️ Reduces migraine attacks by 70%*

✔️ All natural & Clinically studied Ingredients

✔️ Just 2 Capsules per day

Ingredients

How does migradex works?

5 unique mechanism of migradex

1) Vascular Muscle Relaxation:
The combination helps regulate vascular tone by reducing levels of nitric oxide, prostaglandins, and histamine in blood vessels, thereby decreasing both the frequency and intensity of migraine attacks.

2) Neuroinflammation Reduction:
Riboflavin and magnesium work synergistically to decrease neuronal inflammation, moderating nerve transmission and reducing attack frequency. This dual-action approach helps maintain neural homeostasis.

3) CGRP Inhibition:
CoQ10 lowers the level of Calcitonin Gene-Related Peptide (CGRP), a key pain signaling protein. This mechanism significantly reduces monthly migraine occurrences.

4) Homocysteine Regulation:
Elevated homocysteine levels, often associated with MTHFR gene mutations, are a significant migraine trigger. Vitamin B6 and folate facilitate homocysteine metabolism, helping to prevent attacks through improved methylation.

5) Mitochondrial Support:
Migraines are frequently linked to mitochondrial dysfunction caused by nutritional deficiencies. This comprehensive formula addresses these deficits by providing essential vitamins and magnesium, supporting optimal mitochondrial function.

How Long it takes to see full effect

Migradex starts working within 2-3 weeks. Since every individual is different, it might take 4-12 weeks to see the full effect*

Can i take migradex with other prescription medications?

Absolutely! Migradex is a natural formulation that can be taken with other prescription medications. However, it’s always a good idea to talk to your healthcare professional.*

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migradex Ingredients Praised

 
 

See how migradex changes life

92%

Experienced better overall quality of life¹*

85%

Noticed that migradex has significantly reduces number of migraine attacks by 70 %.¹*

76%

Noticed that migradex reduces migraine symptoms by 72%.¹*

¹ based on migradex's ingredients human studies

From 20 migraines/month to 5 !

Every migraine sufferer should take migradex!

My family thanks migradex everyday

Science behind migradex

Magnesium + Vitamin D

Vitamin D increases magnesium's absorption and utilization leading to better effect at lower dose

Riboflavin + Magnesium + Vit B6

These unique combination increases each other's absorption and works synergistically to reduce number of attacks

Feverfew + Vit B1 + CoQ10

This trio will not only reduces number of attacks but also reduces severity of attack so you dont have to keep taking harsh abortive pills

Vascular Muscle Relaxation

Neuroinflammation Reduction

CGRP Inhibition

Homocysteine Regulation

Mitochondrial Support

The combination helps regulate vascular tone by reducing levels of nitric oxide, prostaglandins, and histamine in blood vessels, thereby decreasing both the frequency and intensity of migraine attacks.

Riboflavin and magnesium work synergistically to decrease neuronal inflammation, moderating nerve transmission and reducing attack frequency. This dual-action approach helps maintain neural homeostasis.

CoQ10 lowers the level of Calcitonin Gene-Related Peptide (CGRP), a key pain signaling protein. This mechanism significantly reduces monthly migraine occurrences.

Elevated homocysteine levels, often associated with MTHFR gene mutations, are a significant migraine trigger. Vitamin B6 and folate facilitate homocysteine metabolism, helping to prevent attacks through improved methylation.

Migraines are frequently linked to mitochondrial dysfunction caused by nutritional deficiencies. This comprehensive formula addresses these deficits by providing essential vitamins and magnesium, supporting optimal mitochondrial function.

Ingredients

Each Ingredient is accurately dosed by pharmacist referencing more than 104 human studies to provide maximum efficacy.

Magnesium (bisglycinate)

Riboflavin

Coenzyme Q10

Thiamine

Feverfew

Vitamin B6

Vitamin D3

Folic acid

Magnesium (bisglycinate)

Over 60% Americans have magnesium deficiency. This essential mineral helps relax blood vessels, reducing the chance of migraine attacks. It's also known to ease stress, a common migraine trigger, making it essential in migraine management.*

Riboflavin

Also known as Vitamin B2, is great at reducing sensitivity to light, a major migraine trigger. By reducing light sensitivity, it can lower how often migraines happen and how bad they feel.*

Coenzyme Q10

CoQ10 increases cellular energy production and regulates serotonin and dopamine levels in the brain. These neurotransmitters improves mood and pain perception, making CoQ10 effective in reducing both frequency and severity.*

Thiamine

Thiamine helps with energy metabolism, ensuring optimal brain cell function. It reduces frequency and severity of by resisting triggers.*

Feverfew

Used for centuries, this herb stabilizes mood and helps with migraines by inhibiting inflammatory histamines. It promotes overall brain health, relaxes tension, and improves blood flow.*

Feverfew - migradex natural ingredient for migraine prevention

Vitamin B6

Vitamin B6 (Pyridoxine) increases metabolism of homocysteine. homocysteine is directly linked to migraine attacks. It also reduces stress and blood vessel inflammation.*

Vitamin D3

81.6% migraine patients in clinical study had low vitamin D. By promoting healthy sleep and mood, it reduces migraine risk, as disrupted sleep and mood disturbances are common triggers. Vitamin D may also lower the risk of autoimmune reactions contributing to migraines.*

Folic acid

Folic acid plays major role in mitochondria energy generation. It also increases breakdown of homecysteine. It reduces frequency and severity.*

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Is migradex Safe?

Yes, migradex is made with all natural ingredients that are generally considered safe when taken as directed. However, it is important to consult with your healthcare provider before starting any new supplement, especially if you have underlying health conditions or are taking other medications such as warfarin (coumadin)*

Who should not take migradex?

migradex should not be used by children less than 18 years of age and pregnant and breastfeeding mothers.*

No Butterbur?

Many clinical trials suggest that butterbur is very effective in reducing migraine attacks. However, the American Headache Society no longer recommends the use of butterbur as it contains pyrrolizidine alkaloids (PAs), which can cause liver damage. We tested seven different PA-free extracts and found that all of them contained trace amounts of PAs. Since safety is our first priority, we decided not to include butterbur in our formulation.*

Urine color change?

The change in urine color is due to riboflavin (vitamin B2). Excess riboflavin is excreted via urine, which can change its color to bright yellow or orange. This color change is completely harmless and indicates that your body is utilizing the vitamins effectively.*

How migradex compares to prescription medications

There are very few prescription options available for preventing migraines, and most of them have undesirable side effects. Being a natural formulation, Migradex doesn't have side effects and works just as well, if not better. Additionally, Migradex targets root causes like nutritional deficiencies and homocysteine metabolism that prescription medications doesn't.*

What is Auto delivery?

Always forget to order supplements? Choose our convenient auto-delivery option and receive one bottle of Migradex delivered to your address every month. This way, you'll never have to worry about running out or placing manual order. Plus, we prioritize your supply, ensuring you always have migradex before you run out. You can easily skip or cancel the auto-delivery option at any time.

  • ''

    Less Migraines, Stable Paycheck - Thank you!

    Migradex has really helped cut down how often I get migraines, making it easier for me to focus and get things done at work without having to call in sick. It's made a big difference in my job and how I feel every day.

    Shannon P

  • ''

    I can finally attend my son's Hockey games

    Migradex has changed everything for me. Before, migraines stole precious family time and kept me from my son's hockey games. Now, with fewer migraines, I enjoy more moments with my family and never miss a game

    Mark G

  • ''

    So convenient to take all vitamins together

    my specialist suggested to take 7 vitamins everyday. i hated taking 7 pills every morning. now i only take 2 pills of migradex and with subscription, it just auto delivers before i run out.

    Sherry F

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Customer Reviews

Based on 92 reviews
75%
(69)
24%
(22)
1%
(1)
0%
(0)
0%
(0)
M
Melinda S.

It took way too long to be delivered.

j
julie wolff
AWESOME PRODUCT!

EXCELLENT PRODUCT, WELL WORTH THE MONEY. IT HAS WORKED FOR ME-UNTIL WE GET A SNOW/WEATHER FRONT COMING THROUGH-MY HEAD IS A BAROMETER. BUT OVERALL I'M VERY PLEASED. :)

K
Karen
Life Saver

It has been 48 days since my last major migraine. I had been getting them 11 days apart for the past year. Not only has it worked wonders, but the customer service has been absolutely wonderful. I needed my monthly delivery upped a little bit and I got an email response quickly and they changed my delivery. Their customer service is excellent! It really makes a difference.

A
Anonymous
I have my life back!

I have had debilitating migraines for 52 years. After my car accident 14 years ago, they’ve been coming with more frequency. Nothing has helped. Then a migraine support group told me about Migradex. It reduced my migraines from 2 to 3 times a week to once every two weeks and the severe, severe migraines every 11 days to every six weeks. It is a lifesaver. I have my life back!

s
sherry
great formulation

Great combination of the things my health team suggested I take for migraines. So nice to not need to take all of these separately.

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Clinical References

Riboflavin (Vitamin B2)

  1. Experimental and Clinical Evidence of the Effectiveness of Riboflavin on Migraines. Nutrients2021, 13, 2612. LINK
  2. Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. Int. J. Mol. Sci. 2020, 21, 950 LINK
  3. Effect of riboflavin status on the homocysteine lowering effect of folate in relation to the MTHFR (C677T) genotype. Clin. Chem. 2003, 49, 295–302. LINK
  4. Oral riboflavin in migraine prophylaxis: An open label randomized controlled trial. Neurol. Asia 2011, 16, 223–229. LINK
  5. Riboflavin as a photosensitizer. Effects on human health and food quality. Food Funct. 2012, 3, 487–502. LINK
  6. Dietary intake of thiamine and riboflavin in relation to severe headache or migraine: A cross-sectional survey. LINK
  7. Boehnke, C., et al. High-dose riboflavin treatment is efficacious in migraine prophylaxis: an open study in a tertiary care centre. Eur J Neurol, 2004. PMID: 15272863
  8. Schoenen, J., et al. Effectiveness of high-dose riboflavin in migraine prophylaxis. Neurology, 1998. PMID: 9484373

Coenzyme Q10

  1. Sandor, P. S., et al. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial. Neurology, 2005. PMID: 15728297
  2. Hershey, A. D., et al. Coenzyme Q10 deficiency and response to supplementation in pediatric and adolescent migraine. Headache, 2007. PMID: 17305328

Feverfew

  1. Johnson, E. S., et al. Efficacy of feverfew as prophylactic treatment of migraine. BMJ, 1985. PMID: 3927985
  2. Murphy, J. J., et al. Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet, 1988. PMID: 2899772

Vitamin D

  1. Zandifar, A., et al. Vitamin D status in migraine patients: a case-control study. Biomed Res Int, 2014. PMID: 24729938
  2. Gazerani, P., et al. A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine. Curr Med Res Opin, 2019. PMID: 30588823

Vitamin B1 (Thiamine)

  1. Altura, B. M., & Altura, B. T. Magnesium, thiamine and vascular tone and reactivity: relationship to migraine. Magnesium, 1982. PMID: 6761562

Vitamin B6

  1. Menon, S., et al. The role of MTHFR gene variants in migraine. Mol Genet Metab, 2011. PMID: 21546185
  2. Peikert, A., et al. Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia, 1996. PMID: 8823975

Folic Acid

  1. Frosst, P., et al. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet, 1995. PMID: 7647779
  2. Lea, R., et al. The use of vitamin supplements in the treatment of migraine. Med Hypotheses, 2004. PMID: 15288371

Magnesium

  1. Mauskop, A., & Altura, B. T. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci, 1998. PMID: 9533522
  2. Ramadan, N. M., et al. Low brain magnesium in migraine. Headache, 1989. PMID: 2618945